Hydroxychloroquine-induced hyperpigmentation in a patient with anti-synthetase syndrome

Claúdia Brazão, Dermatology and Venereology Department, Hospital de Santa Maria, Unidade Local de Saúde Santa Maria, Lisbon, Portugal; Dermatology and Venereology University Clinic, Faculty of Medicine, University of Lisbon, Lisbon, Portugal Raquel Campanilho-Marques, Department of Rheumatology, Hospital de Santa Maria, Unidade Local de Saúde Santa Maria; Pediatric Rheumatology Unit, Hospital de Santa Maria, Unidade Local de Saúde Santa Maria; Rheumatology Research Unit, iMM João Lobo Antunes, University of Lisbon. Lisbon, Portugal Pedro de Vasconcelos, Dermatology and Venereology Department, Hospital de Santa Maria, Unidade Local de Saúde Santa Maria, Lisbon, Portugal; Dermatology and Venereology University Clinic, Faculty of Medicine, University of Lisbon, Lisbon, Portugal Luís Soares-de-Almeida, Dermatology and Venereology Department, Hospital de Santa Maria, Unidade Local de Saúde Santa Maria, Lisbon, Portugal; Dermatology and Venereology University Clinic, Faculty of Medicine, University of Lisbon, Lisbon, Portugal Paulo Filipe, Dermatology and Venereology Department, Hospital de Santa Maria, Unidade Local de Saúde Santa Maria, Lisbon, Portugal; Dermatology and Venereology University Clinic, Faculty of Medicine, University of Lisbon, Lisbon, Portugal; Dermatology Research Unit, iMM João Lobo Antunes, University of Lisbon, Lisbon, Portugal

Hydroxychloroquine is a widely prescribed antimalarial drug to treat immune-mediated diseases, with a good safety profile. We present the case of a 37-year-old woman, Fitzpatrick’s phototype IV, who presented to our outpatient Dermatology Department with a 1-year history of symmetrical blue-gray discoloration on the anterior aspect of the legs. The patient had a diagnosis of anti-synthetase syndrome, treated with prednisolone, hydroxychloroquine, rituximab, cyclosporine, and acetylsalicylic acid. The blood work was unremarkable. The skin biopsy revealed hemosiderin and melanin (Perl’s and Fontana-Masson staining) deposits inside dermal histocytes. The diagnosis of antimalarial-induced hyperpigmentation was established. Cutaneous blue-gray discoloration is a common antimalarial skin toxicity, mainly in women with darker skin. Its pathophysiology is unclear, but local trauma, ultraviolet radiation, and the concomitant use of corticosteroids, anticoagulants, and antiplatelet drugs seem to contribute as triggers. This case illustrates that a high level of suspicion and adequate clinicopathologic correlation is necessary to establish a correct diagnosis.

Keywords: Antimalarials. Drug-induced abnormalities. Hydroxychloroquine. Hyperpigmentation. Idiopathic inflammatory myopathies.