- 2025, Volume 83 - Number 1
- Published: November 20, 2024
Late-onset Parry–Romberg syndrome in a patient with newly diagnosed HIV-2 infection
Cláudia Brazão 1, Dora Mancha 2, Lanyu Sun 3, Sofia Antunes-Duarte 4, Diogo de Sousa 4, Pedro de Vasconcelos 5, Luís Soares-de-Almeida 6, Paulo L. Filipe 7
1 Serviço de Dermatologia, ULS Santa Maria. Portugal; 2 Department of Dermatology, Hospital de Santa Maria, Unidade Local de Saúde Santa Maria, Lisbon, Portugal; Dermatology University Clinic, Faculdade de Medicina, Universidade de Lisboa, Lisbon, Portugal; 3 Serviço de Dermatologia, Unidade Local de Saúde Santa Maria, Lisbon, Portugal; 4 Dermatology and Venereology Department, Hospital de Santa Maria, Unidade Local de Saúde Santa Maria, Lisbon, Portugal; Dermatology and Venereology University Clinic, Faculty of Medicine, University of Lisbon, Lisbon, Portugal; 5 Dermatology and Venereology Department, Hospital de Santa Maria, Unidade Local de Saúde Santa Maria, Lisbon, Portugal; 6 Dermatology and Venereology Department, Hospital de Santa Maria, Unidade Local de Saúde Santa Maria; Dermatology and Venereology University Clinic, Faculty of Medicine, University of Lisbon; Dermatology Research Unit, iMM João Lobo Antunes, University of Lisbon. Lisbon, Portugal; 7 Department of Dermatology and Venereology, Unidade Local de Saúde Santa Maria; Faculdade de Medicina da Universidade de Lisboa, Dermatology Clinic. Lisbon, Portugal
Cláudia Brazão, Dora Mancha, Lanyu Sun, Sofia Antunes-Duarte, Diogo de Sousa, Pedro de Vasconcelos, Luís Soares-de-Almeida, Paulo L. Filipe
La información completa de afiliaciones y autor de correspondencia está disponible en la versión original en PDF.
*Correspondence: Cláudia Brazão, Email not available
Abstract
Sclerodermoid syndromes encompass a wide spectrum of rare diseases, with variable clinical presentation and severity. We present a case of a 31-year-old woman, Fitzpatrick’s phototype V, who presented to our dermatology department with a 5-year history of linear atrophy of her right hemiface, which rapidly progressed during the first 2 years and then stabilized. There were no identifiable triggers, namely, drugs, infections, or trauma. Physical examination revealed a linear depression on her right hemiface, alongside a mild right enophthalmos. Laboratory examination revealed a positive human immunodeficiency virus (HIV) type 2 serology, with detectable viral load. The skin biopsy was compatible with late-stage morphea. The diagnosis of Parry–Romberg syndrome and HIV-2 infection was established. This patient illustrates a case of late-onset Parry–Romberg syndrome, in which HIV-2 infection may have been the trigger, due to a possible mechanism of molecular mimicry.
