- 2023, Volume 81 - Number 3
- Published: October 3, 2023
Hand, foot, and mouth disease and palmoplantar erythrodysesthesia in a breast cancer patient: a challenging diagnosis
Dora Mancha 1, Cláudia Brazão 2, Pedro M. Garrido 3, Luís Soares-de-Almeida 4, Paulo L. Filipe 5
1 Department of Dermatology, Hospital de Santa Maria, Unidade Local de Saúde Santa Maria, Lisbon, Portugal; Dermatology University Clinic, Faculdade de Medicina, Universidade de Lisboa, Lisbon, Portugal; 2 Serviço de Dermatologia, ULS Santa Maria. Portugal; 3 Department of Dermatology and Venereology, Instituto Português de Oncologia de Lisboa, Lisbon, Portugal; 4 Dermatology and Venereology Department, Hospital de Santa Maria, Unidade Local de Saúde Santa Maria; Dermatology and Venereology University Clinic, Faculty of Medicine, University of Lisbon; Dermatology Research Unit, iMM João Lobo Antunes, University of Lisbon. Lisbon, Portugal; 5 Department of Dermatology and Venereology, Unidade Local de Saúde Santa Maria; Faculdade de Medicina da Universidade de Lisboa, Dermatology Clinic. Lisbon, Portugal
Dora Mancha, Cláudia Brazão, Pedro M. Garrido, Luís Soares-de-Almeida, Paulo L. Filipe
La información completa de afiliaciones y autor de correspondencia está disponible en la versión original en PDF.
*Correspondence: Cláudia Brazão, Email not available
Abstract
Cancer patients may experience several dermatological symptoms during treatment. We describe a case of synchronous presentation of hand, foot, and mouth disease (HFMD) and palmoplantar erythrodysesthesia (PPE) in a breast cancer patient. A 36-year-old female breast cancer patient under chemotherapy presented to our consult with a 1-week history of painful palmoplantar lesions associated with the recent onset of fever and dry cough. Her daughter had been diagnosed with HFMD. There was a positive immunoglobulin M (IgM) and IgG serology for coxsackievirus. We performed two skin biopsies; one specimen was consistent with HFMD, and the other one was with PPE. To the best of our knowledge, the synchronous presentation of HFMD and PPE has not yet been reported in the literature to date. PPE and immunosuppression might have been responsible for the atypical presentation and clinical severity of HFMD.
