The clinicopathological manifestations and differential diagnoses of mycosis fungoides variants (the great mimickers): a comprehensive review

The clinicopathological manifestations and differential diagnoses of mycosis fungoides variants (the great mimickers): a comprehensive review

Jacob Al-Dabbagh 1, Nemat Ismail 1, Moath Alsoleman 2, Eman Mohammad-Deeb 1, Lina Al-Soufi 1, Zuheir Al-Shehabi 3

1 Faculty of Medicine, Tishreen University, Latakia, Syria; 2 Faculty of Medicine, Damascus University, Damascus, Syria; 3 Cancer Research Center, Tishreen University, Latakia, Syria

Jacob Al-Dabbagh, Nemat Ismail, Moath Alsoleman, Eman Mohammad-Deeb, Lina Al-Soufi, Zuheir Al-Shehabi

La información completa de afiliaciones y autor de correspondencia está disponible en la versión original en PDF.

*Correspondence: Eman Mohammad-Deeb, Email not available

Abstract

Mycosis fungoides (MF) is the most prevalent type of primary cutaneous T-cell lymphoma (CTCL), which is considered a great imitator due to the wide spectrum of its clinical manifestations that can mimic numerous skin disorders. MF can also resemble a wide range of dermatoses on histopathological and clinicopathological bases. The various clinical and histopathological manifestations of MF often lead to missing or delaying the diagnosis, which leads to a poorer prognosis as a consequence. In this article, we presented a comprehensive review of the clinical presentations and differential diagnoses of the clinical, histopathological, and clinicopathological variants of MF with a focus on the histopathologic manifestations of each variant.

Keywords:  Cutaneous lymphoma. Cutaneous T-cell lymphoma. Mycosis fungoides. Mycosis fungoides variants. Skin cancer.

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