- 2026, Volume 84 - Number 1
- Published: March 26, 2026
Eccrine spiradenoma: three case reports
Rafael B. Santos 1 
, Maria J. Cruz 2, Manuel B. Costa 1, Filipe Cruz 2, Roberto P. Silva 3, Elisabete Rios 3, Carolina A. Leal 3, João M. Magalhães 3, Maria H. Bessa 2
1 Department of Dermatology and Venereology, Unidade Local de Saúde de São João, Porto, Portugal; 2 Department of General Surgery, Unidade Local de Saúde de São João, Porto, Portugal; 3 Department of Pathology, Unidade Local de Saúde de São João, Porto, Portugal
Rafael B. Santos, Maria J. Cruz, Manuel B. Costa, Filipe Cruz, Roberto P. Silva, Elisabete Rios, Carolina A. Leal, João M. Magalhães, Maria H. Bessa
La información completa de afiliaciones y autor de correspondencia está disponible en la versión original en PDF.
*Correspondence: Rafael B. Santos. Email: rafaellbss@gmail.com
Abstract
Eccrine spiradenoma is a rare benign adnexal tumor, usually presenting as a painful solitary cutaneous nodule. We report three histologically confirmed cases in male patients aged 38 to 62 years, with lesions located on the right arm, forearm, and anterior hemithorax. Only one patient reported pain, underscoring the variability of clinical symptoms. All tumors exhibited the classic biphasic cell population and basement membrane material, without atypia or mitotic activity. Case 1 also demonstrated lymphoid infiltrates and vascular ectasias, with EMA-positive neoplastic epithelial cells. This series highlights uncommon demographic and anatomical presentations and reinforces the importance of histopathological evaluation for accurate diagnosis of eccrine spiradenoma, particularly in atypical settings.
