Efficacy of ablative carbon dioxide laser in management of xanthelasma palpebrarum

Objectives: The objective of the study is to evaluate the efficacy and safety of ablative carbon dioxide (CO2) laser in the treatment of xanthelasma palpebrarum. Methods: This interventional study included 90 patients aged 18-65 years with grade I-III xanthelasma. Patients with grade IV lesions and significant comorbidities were excluded. Baseline clinical and biochemical evaluation was performed. Lesions were treated with ablative CO2 laser using standardized parameters (60-90 mJ energy, 210 Hz frequency). Patients were followed up monthly for 3 months. Efficacy was assessed using five-point scale score and patient satisfaction score. Results: Most patients were females (85.6%) and belonged to the 25-45-year age group (54.4%). Upper eyelid involvement was predominant (97.8%). Progressive improvement in lesion clearance was observed with >75% clearance achieved in 56.7% patients at 3 months (p = 0.001). At the end of the study, 72.2% patients were verysatisfied. Common adverse effects included erythema, edema, and scabbing. Hypopigmentation was the most frequent complication (65.6%), while recurrence occurred in 5.6% cases. Conclusion: Ablative CO2 laser is a safe and effective treatmentmodality for xanthelasma palpebrarum, offering good cosmetic outcomes with high patient satisfaction and low recurrencerates.